Effective Scale-Up
Analytical chemistry delivers the information to define, improve, and verify technology innovation and enables robust process development. At ABPDU, we engage in continuous process improvement to enable the successful scaling of each unit operation as well as the integrated process.
Using Analytical Chemistry for Continuous Process Improvement
Effect of Fermentation Mode and Temperature at Various Enzyme Loadings
Both fermentation mode and temperature drive the MESP across enzyme loadings
Robust Validation
Knowing the critical importance of accurate data for process validation and improvement, at ABPDU we have exacting standards for data collection and analysis. Among other things, we use extensive analytics to:
- Understand the interaction between various feedstocks and deconstruction methodologies
- Identify fermentation inhibitors
- Obtain detailed recovery data for techno-economic modeling
Precise Quantification
Analytical chemistry is highly dependent on reproducible, robust, and reliable methods that provide precise quantification of the physio-chemical characteristics of a sample. Every project has challenges in sample handling, method selection, and process validation that are unique to that project.
Whenever possible we use protocols and techniques widely recognized by industry, but have the flexibility to adapt these protocols and develop methods customized to each project. Use of validation characteristics, such as accuracy, linearity, and precision ensures that the data provided is of the highest quality.
HPLC Spectra
Our Equipment
GAS CHROMATOGRAPHY
ANALYTICAL RHEOMETER
HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY
ANALYTICAL-YSI GAS ANALYZER
HIGH-PERFORMANCE ANION EXCHANGE CHROMATOGRAPHY
GALLERY AUTOMATED PHOTOMETRIC ANALYZER
BIO RAD GEL-DOC EZ IMAGER
YSL 2900 BIOCHEMISTRY ANALYZER WITH SITINI AUTOSAMPLER
Analytical Chemistry Options
Biomass Composition
Material Physical Properties
Protein Characterization
Related Papers & Publications
Short-chain ketone production by engineered polyketide synthases in Streptomyces albus
Engine tests indicate that short-chain ketones produced using Type I modular polyketide synthases can be added to gasoline as oxygenates to increase the octane of gasoline.
Rhodosporidium Toruloides: A New Platform Organism for Biorefineries
R. toruloides sets a new standard for biotechnological applications
Scale-Up and Process Integration of Municipal Solid Waste Conversion Process
Two case studies exploring conversion technologies for municipal solid waste. One is a partnership INL, and the other is a collaboration with FATER.
Evaluation of Storage Effect on the Biomass Conversion to Sugars
Switchgrass with 10% and 20% dry matter loss and corn stover with 30% dry matter loss achieved higher sugar yields during biomass conversion
Predictive Modeling and Rheological Estimation of Mixed Biomass Feedstocks
Predictive modeling was used to evaluate and optimize traditional pretreatment methods for biomass mixture compositions to maximize sugar yield and minimize furfural production.
Process Scale-up of Municipal Solid Waste and Corn Stover Blends Conversion into Sugars
Municipal solid waste and corn stover blends present great potential to meet quality and cost requirements for sugar conversion.
Determining the Impact of MSW as a Feedstock Blending Agent on Pretreatment Efficacy
The collaboration with INL and SNL demonstrated 600-fold (10mL to 6L) scale up of MSW/CS blends.
Process Development of Three Novel High Value Fermentation Products
Successful scale-up of the fermentation pathway for Lygos’ bio-malonic acid production.
FATER ABPDU Waste-to-Bioenergy Process Partnership
Post-consumer absorbent hygiene products can be economically converted to fermentable sugar intermediates, biofuels, and bio-based products
Predictive Modeling Can De-Risk Bio-based Production
Technologies developed to generate bio-based products are based on single feedstock types. While this approach is applicable for corn stover in the MidWest, for states such as California, with abundant but diverse feedstocks, technologies should be developed to accommodate multiple feedstock input to a single biorefinery.
